Y-27632 2HCL

SKU: orb154626

Description

Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM.

Key Properties

• CAS Number: 129830-38-2
• MW: 320.26
• Formula: C₁₄H₂₃Cl₂N₃O
• SMILES: C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

Storage & Handling

• Storage: Can be stored for 2 years at -20°C in powder form, 2 weeks at 4°C in DMSO, and 6 months at -80°C in DMSO.
• Expiration Date: 12 months from date of receipt.
• Hazard Information: Non-Toxic
• Disclaimer: For research use only

Chemical structure of Y-27632 2HCL.

Y-27632 2HCL

Barbora Schwarzova, Tim Studemann, Muhammed Sonmez, Judith Rossinger, Bangfen Pan, Thomas Eschenhagen, Justus Stenzig, J. Simon Wiegert, Torsten Christ & Florian Weinberger Modulating cardiac physiology in engineered heart tissue with the bidirectional optogenetic tool BiPOLES Pflugers Arch., (2023)

Applications

Cell Culture

Reactivity

Human

Karl T Wagner 1, Rick X Z Lu 1, Shira Landau 1, Sarah A Shawky 2, Yimu Zhao 1, David F Bodenstein 1, Luis Felipe Jiménez Vargas 1, Richard Jiang 3, Sargol Okhovatian 1, Ying Wang 1, Chuan Liu 1, Daniel Vosoughi 4, Dakota Gustafson 4, Jason E Fish 5, Carolyn L Cummins 6, Milica Radisic 1 Endothelial extracellular vesicles enhance vascular self-assembly in engineered human cardiac tissues Biofabrication, (2024)

PubMed: 39226913

J Raabe, I Wittig, P Laurette, K Stathopoulou, T Brand Physioxia rewires mitochondrial complex composition to protect stem cell viability Redox Biology, (2024)

Mireia Nàger 1, Kenneth B Larsen 2 3, Zambarlal Bhujabal 2, Trine B Kalstad 2, Judith Rössinger 4, Truls Myrmel 1 2, Florian Weinberger 4 5, Asa B Birgisdottir Mitophagy is induced in human engineered heart tissue after simulated ischemia and reperfusion J Cell Sci ., (2025)

PubMed: 39912384

Anca Kliesow Remes # 1 2, Theresa Ruf # 3 4, Tinatin Zurashvili 1 5, Lin Ding 3 6, Moritz Meyer-Jens 2 7, Dominic M Schwab 3, Susanne Hille 1 2, Andrea Matzen 2 6, Sabine Michalewski 1 2, Lucia Kilian 2 6, Prithviraj Manohar Vijaya Shetty 1 2, Marie-Christin Fuchs 3, Matthias Eden 3 4 6, Hermann-Josef Gröne 8, Kleopatra Rapti 3, Andreas Jungmann 3, Hendrik Milting 9, Hugo A Katus 3 4, Lucie Carrier 2 7, Derk Frank 2 6, Norbert Frey 3 4, Oliver J Müller AAV-mediated overexpression of CPT1B protects from cardiac hypertrophy and heart failure in a murine pressure overload model Basic Res Cardiol, (2025)

PubMed: 40646338

Laura Sen-Martín et al. Mavacamten shows broad benefit in human and mouse models of MYBPC3-related hypertrophic cardiomyopathy Nat Cardiovasc Res, (2026)

PubMed: 42414613

Applications

Cell Culture

Reactivity

Human

Nancy Sorial Samy Shehata Evidence for the inhibition of cardiomyocytes cycle activity by cardiac contraction Natural Sciences University of Hamburg, (2026)

Applications

Cell Culture