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Afatinib
SKU: orb1305744
Description
Research Area
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Images & Validation
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Key Properties
−| CAS Number | 439081-18-2 |
|---|---|
| MW | 485.94 |
| Purity | 99.22% (May vary between batches) |
| Formula | C24H25ClFN5O3 |
| SMILES | CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 |
| Target | Autophagy,c-Met/HGFR,Akt,HER,EGFR,p38 MAPK,Apoptosis |
| Solubility | DMSO:250 mg/mL (514.47 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:12 mg/mL (24.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:9 mg/mL (18.52 mM) |
Storage & Handling
−| Storage | -20°C |
|---|---|
| Expiration Date | 12 months from date of receipt. |
| Disclaimer | For research use only |
Alternative Names
−Afatinib, BIBW2992, BIBW 2992, BIBW-2992, HER2, HER4, EGFR (wt), EGFR (L858R/T790M), EGFR (L858R)
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Gene Symbol
Autophagy,c-Met/HGFR,Akt,HER,EGFR,p38 MAPK,Apoptosis
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Afatinib (orb1305744)
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