Colchicine

SKU: orb1310726

Description

Colchicine is a potent natural alkaloid that inhibits microtubule polymerization (IC50 = 3 nM) and acts as a competitive glycine receptor antagonist. It is widely used in research for its anti-inflammatory and immunosuppressive properties, applied in studies of gout, rheumatoid arthritis, Alzheimer's disease models, and NLRP3 inflammasome-related pathologies in both cellular and animal studies.

Research Area

Cell Biology

Key Properties

• CAS Number: 64-86-8
• MW: 399.45
• Purity: >98%
• Formula: C₂₂H₂₅NO₆
• SMILES: COC1=C(OC)C(OC)=C2C(CCC(NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1
• Target: Cytoskeleton
• Solubility: Soluble in DMSO (up to 25 mg/ml), in Water (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

microtubule, MicrotubuleAssociated, Microtubule/Tubulin, Microtubule Associated, inhibit, Inhibitor, Apoptosis, Autophagy, Colchicine, Colchineos, Colchisol, Colcin

Quick Database Links

Gene Symbol

Cytoskeleton