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FIIN-2

SKU: orb1223255

Description

FIIN-2 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-2 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-2 also binds in the DFG-out mode despite lacking a functional group necessary to occupy the pocket vacated upon the DFG-out flip.

Images & Validation

Key Properties

CAS Number1633044-56-0
MW634.73
Purity>98% (HPLC)
FormulaC35H38N8O4
SMILESCN1CCN(CC1)c1ccc(cc1)Nc1ncc2CN(C(=O)N(c2n1)Cc1ccc(cc1)NC(=O)C=C)c1cc(cc(c1)OC)OC
TargetDopamine Receptor
SolubilityDMSO : ≥ 30 mg/mL 47.26 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

FIIN2 | FIIN 2 | FIIN-2

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  • FIIN-3 [orb1223253]

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FIIN-2 (orb1223255)

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$ 90.00
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