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FIIN-2

SKU: orb1300421

Description

FIIN-2 is an irreversible pan-FGFR inhibitor exhibiting potent activity against FGFR1-4 with IC50 values of 3.09, 4.3, 27, and 45.3 nM, respectively. It is a valuable chemical probe for studying FGFR-driven pathologies in both cellular assays and preclinical cancer models.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number1633044-56-0
MW634.73
Purity97.82% (May vary between batches)
FormulaC35H38N8O4
SMILESCOc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc2N(Cc2ccc(NC(=O)C=C)cc2)C1=O
TargetFGFR
SolubilityH2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:64 mg/mL (100.83 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.15 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, Fibroblast growth factor receptor, FGFR2, FGFR, FGFR1, FGFR4, FGFR3, FIIN 2, FIIN2, FIIN-2, inhibit

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FIIN-2 (orb1300421)

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Available Sizes

Select a size below

1 mg
$ 80.00
2 mg
$ 90.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 140.00
10 mg
$ 140.00
25 mg
$ 250.00
50 mg
$ 360.00
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