GNF-2

SKU: orb1307386

Description

GNF-2 is a potent, selective inhibitor that targets Bcr-Abl through a unique allosteric, non-ATP-competitive mechanism. It is a valuable chemical probe for studying kinase signaling in chronic myeloid leukemia (CML) research, demonstrating activity in both cellular and animal models of the disease.

Research Area

Cardiovascular Research, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 778270-11-4
• MW: 374.32
• Purity: ≥95% (May vary between batches)
• Formula: C₁₈H₁₃F₃N₄O₂
• SMILES: NC(=O)c1cccc(c1)-c1cc(Nc2ccc(OC(F)(F)F)cc2)ncn1
• Target: Bcr-Abl,SARS-CoV
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.34 mM);Ethanol:18.7 mg/mL (49.96 mM);DMSO:37.4 mg/mL (99.91 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, GNF 2, GNF2, GNF-2, inhibit, non-ATP competitive inhibitor, allosteric, BcrAbl, Bcr-Abl, Bcr-Abl (K562 cell line), Bcr-Abl (SUP-B15 cell line), bone erosion, Ba/F3.p185Y253H, Ba/F3.p210, Ba/F3.p210E255V, SARS coronavirus, SARS-CoV, SARSCoV

Quick Database Links

Gene Symbol

Bcr-Abl,SARS-CoV