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GNF-5

SKU: orb1224017

Description

GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.22±0.1 uM (Wild type Abl).

Images & Validation

Key Properties

CAS Number778277-15-9
MW418.37
Purity>98% (HPLC)
FormulaC20H17F3N4O3
SMILESO=C(NCCO)C1=CC=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=C1
TargetBcr-Abl
SolubilityEthanol: 20 mg/mL warmed (47.8 mM); DMSO: 83 mg/mL (198.38 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GNF-5 | GNF 5 | GNF5.

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GNF-5 (orb1224017)

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