GNF-5

SKU: orb1307410

Description

GNF-5 is a non-ATP competitive Bcr-Abl inhibitor with an IC50 of 0.22 µM against wild-type Abl. As a pharmacokinetically improved analog of GNF-2, it is a valuable chemical probe for studying kinase-independent oncogenic signaling in chronic myeloid leukemia research, both in vitro and in vivo.

Research Area

Cardiovascular Research, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 778277-15-9
• MW: 418.37
• Purity: 98.00% (May vary between batches)
• Formula: C₂₀H₁₇F₃N₄O₃
• SMILES: N(C1=CC(=NC=N1)C2=CC(C(NCCO)=O)=CC=C2)C3=CC=C(OC(F)(F)F)C=C3
• Target: Bcr-Abl,SARS-CoV
• Solubility: Ethanol:16 mg/mL (38.24 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.78 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:16.67 mg/mL (39.85 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chronic myelogenous leukemia (CML), Bcr-Abl, BcrAbl, cancer, GNF5, GNF-5, GNF 5, GNF-2, Inhibitor, inhibit, pharmacokinetic, SARSCoV, SARS-CoV

Quick Database Links

Gene Symbol

Bcr-Abl,SARS-CoV