Trametinib

SKU: orb1306425

Description

Trametinib is an orally active, ATP-noncompetitive inhibitor of MEK1 and MEK2 (IC50=0.7/0.9 nM). It is widely used in cancer research to study pathways involving cell proliferation and survival, as it can induce autophagy and apoptosis in both in vitro and in vivo models.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 871700-17-3
• MW: 615.4
• Purity: >98%
• Formula: C₂₆H₂₃FIN₅O₄
• SMILES: N(C1=C2C(N(C(=O)N(C2=O)C3CC3)C4=CC(NC(C)=O)=CC=C4)=C(C)C(=O)N1C)C5=C(F)C=C(I)C=C5
• Target: Kinase
• Solubility: Soluble in DMSO (up to 20 mg/ml with warming)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK1120212; JTP-74057

Quick Database Links

Gene Symbol

Kinase