Ursodeoxycholic acid

SKU: orb1226618

Description

Ursodiol reduces cholesterol absorption and is used to dissolve gallstones.(In Vitro):Ursodeoxycholic acid (10 μM; 24 h) reduces ACE2 and SHP levels in primary airway and intestinal organoids, and reduces SARS-CoV-2 infection in multiple cell types via FXR-mediated ACE2 regulation.\n(In Vivo):Ursodeoxycholic acid (50, 150, and 450 mg/kg; p.o.; daily for 21 days) results in weight loss in C57BL/6J wildtype mice.Ursodeoxycholic acid (1% w/w or 416 mg/kg; oral; 7 days) reduces ACE2 expression in mice and hamsters.Ursodeoxycholic acid (416 mg/kg; oral; 7 days) reduces SARS-CoV-2 infection in hamsters.

Key Properties

• CAS Number: 128-13-2
• MW: 392.57
• Purity: >98% (HPLC)
• Formula: C₂₄H₄₀O₄
• SMILES: C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C
• Target: Potassium Channel
• Solubility: Ethanol: 79 mg/mL (201.23 mM); DMSO: 79 mg/mL (201.23 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Potassium Channel