Y-27632

SKU: orb1307291

Description

ZY-27632 is a potent, cell-permeable inhibitor of ROCK-I and ROCK-II kinases. It is widely used in vitro to study cytoskeletal dynamics and cell adhesion, and in vivo to investigate its role in apoptosis prevention, such as in isolated prostate progenitor cells.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 146986-50-7
• MW: 247.34
• Purity: 99.53% (May vary between batches)
• Formula: C₁₄H₂₁N₃O
• SMILES: C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
• Target: ROCK,Apoptosis
• Solubility: DMSO:127.5 mg/mL (515.48 mM);H2O:insoluble;10% DMSO+90% Saline:2.48 mg/mL (10.03 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, inhibit, Inhibitor, Y27632, Y-27632, Y 27632, Rho-associated protein kinase, Rho-kinase, Rho-associated kinase, ROK, ROCK2, ROCK1, ROCK

Quick Database Links

Gene Symbol

ROCK,Apoptosis

Jane In den Birken et al. Investigating the Anticancer Effects of Sulforaphane in an In Vitro Coculture Model of Prostate Cancer Cells with Engineered Heart Tissue ACS Pharmacol Transl Sci, (2025)

PubMed: 41409171

Nicola Wanner et al. Lysine-specific histone demethylase 1a regulates nephron development and long-term transcriptional programming JCI Insight, 11(5), e190283 (2026)

PubMed: 41797715

Applications

Cell Culture

Reactivity

Human