Imatinib

SKU: orb1300957

Description

Imatinib (STI571) is an orally active small molecule that potently and selectively inhibits the tyrosine kinases BCR-ABL, PDGFR, and c-Kit. It is widely used in research for chronic myeloid leukemia (CML), gastrointestinal stromal tumors (GIST), and in vitro studies of oncogenic signaling pathways.

Research Area

Cardiovascular Research, Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 152459-95-5
• MW: 493.60
• Purity: 99.42% (May vary between batches)
• Formula: C₂₉H₃₁N₇O
• SMILES: CN1CCN(CC2=CC=C(C=C2)C(=O)NC2=CC(NC3=NC(=CC=N3)C3=CC=CN=C3)=C(C)C=C2)CC1
• Target: SARS-CoV,Bcr-Abl,c-Kit,PDGFR,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (5.06 mM);DMSO:25 mg/mL (50.65 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bcr-Abl, BcrAbl, Autophagy, cKit, c-Kit, CD117, CGP057148B, CGP-57148B, Inhibitor, Imatinib, inhibit, Platelet-derived growth factor receptor, PDGFR, ST1571, ST-1571, ST 1571, SCFR, SARSCoV, SARS coronavirus, SARS-CoV, STI 571, STI571, STI-571, v-Abl

Quick Database Links

Gene Symbol

SARS-CoV,Bcr-Abl,c-Kit,PDGFR,Autophagy

A Cama Fabio Verginelli, Silvia Perconti, Simone Vespa, Francesca Schiavi, Sampath Chandra Prasat, Paola Lanuti gruppootologico.com, (2024)